Magnesium Glycinate 120 Capsules

Bisglycinate is magnesium chelated to two glycine molecules, which allows it to use intestinal peptide transporters (PepT1) rather than the classic ion channels used by salts like magnesium oxide. This absorption pathway is less subject to saturation and competition with other minerals (calcium, iron). A comparative study (Schuette et al., JPEN, 1994) showed that bisglycinate is absorbed markedly better than magnesium oxide, while causing much less digestive discomfort — the real absorption rate of oxide often being very low.

Evening intake is generally recommended: glycine paired with magnesium has a calming effect on the nervous system, which promotes relaxation before bed. For a 2-month course at 2 capsules per day (this product's dosage), you can take both capsules together in the evening with a meal, or split them morning/evening if you'd prefer to spread the intake across the day.

This is actually one of the main advantages of this form: unlike magnesium oxide or citrate, which are often associated with a laxative effect at high doses, bisglycinate is known for its very good digestive tolerance, with no laxative effect at usual doses. That's why this form is often recommended for people with sensitive digestion.

Magnesium and vitamin B6 act synergistically on normal nervous system function: vitamin B6 promotes magnesium's entry into cells and enhances its action. The P-5-P form (pyridoxal-5-phosphate) used here is the active form of B6, directly usable by the body with no prior liver conversion required, unlike standard pyridoxine.

This supplement is generally well tolerated. As with any magnesium supplementation, people with severe kidney failure should consult a doctor before use, since the kidney is the organ that regulates magnesium elimination. Follow the recommended daily dose stated on the packaging and do not exceed it.